Measure Cardiac Output Using Ultrasound Dilution in Mechanically Ventilated Children

Transonic Systems

Status: Completed

Conditions: Post Cardiac Surgery

Study type: Observational

Funder types: Industry

Identifiers

NCT01662141

IRB (Other Identifier)

TSI-S-COstatus-13A-H

Details and patient eligibility

About

The measurement of cardiac output (CO) and hemodynamic pressures are vital for proper management of severely hemodynamic compromised patients. A new ultrasound dilution method (COstatus) for cardiac output measurement has been developed.

Full description

The thermodilution technique with a pulmonary artery catheter has been the standard in adult patients for cardiac output measurement. However, using pulmonary artery catheter remains a major clinical problem in children due to technical and size constraints.

COstatus measures changes in blood ultrasound velocity in an extracorporeal AV loop caused by body-temperature isotonic saline injected into the central vein and calculates cardiac output derived from a dilution curve.

Enrollment: 33 patients

Sex: All

Ages: Under 21 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children <15 kg admitted to pediatric cardiac surgery for corrective surgery and mechanically ventilated were eligible for the study if parents provided informed consent.

Exclusion criteria

• Children with known significant tricuspid or mitral valve regurgitations or if it is detected by the preoperative transesophageal echocardiographic examination.
• Children with persistent severe arrhythmias.
• Children with remaining intracardiac shunts after surgery, which may adversely affect the measurement.