Measure the Serum Level of Homocysteine in Acne Patients Before and After Oral Isotretinoin.

Aswan University

Status and phase

Completed

Phase 4

Conditions

Acne Vulgaris

Treatments

Drug: Isotretinoin

Study type

Interventional

Funder types

Other

Identifiers

NCT05529888

322/1/19

Details and patient eligibility

About

Serum homocysteine level in Acne patients before and after oral Isotretinoin and Correlation between serum level of homocysteine in acne patients before and after Oral isotretinoin treatment

Full description

Acne vulgaris is a common chronic inflammatory disease of the skin. It is found in about 80% of young adults and adolescents. It is a disease that affects the pilosebaceous units of the skin and may result in inflammatory or non-inflammatory lesions,Oral isotretinoin (13-cis-retinoic acid) is the only drug that counteracts all the pathogenetic mechanisms that contribute to the development of acne The standard dose of isotretinoin is 0.5 to 1 mg/kg per day for 4 months to a cumulative dose of 120-140 mg/kg is effective in the management of acne vulgaris The scope of our study is to detect serum homocysteine level in acne patient befor and after oral isotrtinoin treatment

Enrollment

60 patients

Sex

All

Ages

15 to 45 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients of both sexes with acne vulgaris

Exclusion criteria

Patients with history of malignancies.
Patients with renal and hepatic dysfunction.
Cardiac patient.
Pregnant, lactating and female welling to have pregnancy in the period of study.
Patient with absorption disorder.
Patient with history of favism.
Patient has already been treated with isotretinoin.