Measured Hypocretin Levels and Recovery After Hip Surgery
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About
A specific group of neurons in the brain produces hypocretin, a peptide which has been established as an important regulator of sleep and wakefulness. Activation of these neurons (increased hypocretin) stabilizes wakefulness; impairing or blocking these neurons (decreased hypocretin) promotes sleep. Evidence suggests that these neurons may be involved in the hypnotic properties of several anesthetics, and play a role in the induction and emergence from anesthesia. In humans there is a considerable inter-individual variability in hypocretin levels. This study aims to investigate how hypocretin levels affect the anesthetic care and recovery of patients undergoing elective hip surgery.
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Inclusion and exclusion criteria
Inclusion Criteria:- Adult (18 years of age or older)
- Male or female
- Scheduled for elective total hip arthroplasty at the Stanford Orthopedic Clinic.
- Comprehend spoken and written English Exclusion Criteria:- ASA physical status > III (patients with severe systemic disease)
- Diagnosed psychiatric disease (except mild depression)
- Any diagnoses CNS disease or dementia
- History of stroke
- History of untreated thyroid disease
- Difficulty in airway management (ventilation and/or intubation)
- Body Mass Index (BMI) > 35 kg/m2
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Data sourced from clinicaltrials.gov
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