Measurement and Comparison of the Occlusive and Hydrating Capacity of Three Silicone Gels and One Gel Cream

Ghent University Hospital (UZ)

Status: Completed

Conditions: Scar Tissue or Healthy Skin

Treatments: Drug: BAP scar gel; Drug: Mepiform; Drug: Dermatix; Drug: Bap Scar Care S; Drug: Alhydran; Drug: Scar Ban Elastic; Drug: Kelocote; Drug: Bap Scar Care T

Study type: Interventional

Funder types: Other

Identifiers

NCT01413789

2011/350

Details and patient eligibility

About

Study hypothesis: Is Alhydran gel-cream as efficient as silicone gel for skin occlusion and hydration?

For this study 16 volunteers and ten patients with healed full thickness burns will be included.

After a short period of acclimatization four test areas will be determined. For healthy volunteers the standard zones are located on the inner forearm, two on each forearm.

For patients with healed burns the 4 test zones are located on either the healed donor site or the healed skin grafted area.

In each test zone baseline measurements will be taken before application of the products.After application of the three silicone gels and the hydrating gel cream the trans epidermal water loss (TEWL) and the moisture content of the stratum corneum will be measured by using the TEWAmeter®TM300 and the Corneometer® CM825 (Courage & Khazaka).

Enrollment: 55 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy volunteers or patients with healed full thickness burns and donor sites
• not pregnant
• age>18 years
• male or female
• written authorisation of the patient or volunteer is required.

Exclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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55 participants in 1 patient group

Patients and healthy volunteers

Experimental group

Description:

Patients with healed full thickness burns and healthy volunteers will be included in the study

Treatment:

Drug: Dermatix

Drug: Bap Scar Care S

Drug: Alhydran

Drug: Mepiform

Drug: Scar Ban Elastic

Drug: Bap Scar Care T

Drug: Kelocote

Drug: BAP scar gel