Measurement of Anterior Chamber Cell Grading Using Ocular Coherence Tomography

Rutgers The State University of New Jersey

Status: Terminated

Conditions: Uveitis

Treatments: Other: Eye Exam; Device: Optical Coherence Tomography (OCT)

Study type: Interventional

Funder types: Other

Identifiers

NCT02907814

Pro20160000585

Details and patient eligibility

About

Optical Coherence Tomography (OCT) is routinely used in ophthalmic clinical practice. It uses infrared light to image patient's eyes. Some patients, such as those with an inflammatory disease called uveitis or those who have just undergone cataract surgery, have intraocular inflammation. This intraocular inflammation commonly manifests as cells that can be seen on routine microscopic clinical examination. However, the only currently available method to quantify this intraocular inflammation is by manually counting on the microscopic clinical examination. The investigators plan to use the OCT machine to image patient's eyes. The investigators will then use the images obtained from the OCT to objectively quantify the degree of intraocular inflammation.

Enrollment: 6 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age over 18 years old

• Intervention Arm:

  • Active anterior chamber inflammation in at least one eye as diagnosed by clinical exam
  • One of the following: 1) diagnosis of uveitis OR 2) undergone cataract extraction surgery within the previous 30 days

• Control Arm:

  • No active intraocular inflammation based on clinical exam

Exclusion criteria

• Corneal opacities in the affected eye
• Anyone judged unable to understand or consent to study participation

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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6 participants in 2 patient groups

Uveitis and Cataract Imaging Group

Experimental group

Description:

Subjects will undergo up to three optical coherence tomography scans.

Treatment:

Device: Optical Coherence Tomography (OCT)

Control

Experimental group

Description:

Control subjects will undergo a brief, non-contact eye exam and then undergo up to three optical coherence tomography scans.

Treatment:

Other: Eye Exam

Device: Optical Coherence Tomography (OCT)