Measurement of MRP2 Function Using Urinary Coproporphyrins (COVOL)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Healthy Subjects

Study type: Observational

Funder types: Other

Identifiers

NCT00746044

PHAO07-CLG/COVOL

Details and patient eligibility

About

Human Multidrug Related Protein 2 (MRP2) excretes several drugs and could therefore modulate their elimination. Individual's MRP2 activity is under genetic control. Thus it would be very useful to get an easily measurable biomarker reflecting individual's MRP2 activity. We aimed to investigate the ratio of urinary coproporphyrins I and III (UCP(I/I+III), known to be increased in patients with mutations in MRP2/ABCC2 gene.

Enrollment: 40 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• > 18 y
• Affiliated to an health insurance

Exclusion criteria

• Patient not able to understand or to comply to the protocol

Trial design

40 participants in 1 patient group

1

Description:

Healthy volunteers \>18y, 20 male, 20 female