Measurement of Oncostatin M, Leukemia Inhibitory Factor and Interleukin-11 Levels of Patients With Periodontal Disease

Ataturk University

Status: Completed

Conditions: Chronic Periodontitis, Generalized; Gingivitis

Treatments: Procedure: Initial Periodontal Therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT04597073

OncosM,LIF,IL-11

Details and patient eligibility

About

This study aims to determine Oncostatin M (OSM), Leukemia inhibitory factor (LIF), and Interleukin-11 (IL-11) levels in gingival crevicular fluid (GCF), saliva, and serum in periodontally healthy individuals and those with gingivitis and chronic periodontitis before and after periodontal treatment and to evaluate the relationship between these cytokine levels and clinical periodontal parameters.

Enrollment: 72 patients

Sex: All

Ages: 20 to 56 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• systemically healthy
• non-smokers

Exclusion criteria

• smokers
• pregnancy or lactation
• individuals with any systemic disease
• individuals who have had periodontal treatment in the last six months

Trial design

Primary purpose: Screening

Allocation: Non-Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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72 participants in 3 patient groups

Healthy

No Intervention group

Description:

included individuals with probing depth (PD) ≤3mm, no sites with attachment loss, and no radiographic evidence of alveolar bone resorption. They exhibited no sign of inflammation (GI=0).

Gingivitis

Experimental group

Description:

had varying degrees of gingival inflammation (GI≥1), PD≤3mm with no clinical attachment loss or with no alveolar bone destruction.

Treatment:

Procedure: Initial Periodontal Therapy

Chronic Periodontitis

Experimental group

Description:

was defined as those who were with PD ≥ 4mm, clinical attachment loss (CAL) ≥ 2mm, and who had bone loss affecting \>30% of the existing teeth on clinical and radiographic examination.

Treatment:

Procedure: Initial Periodontal Therapy