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Measurement of Optic Nerve Sheath Diameter

K

Keimyung University

Status

Completed

Conditions

Optic Nerve Sheath Diameter

Treatments

Other: thoracic epidural catheterization

Study type

Interventional

Funder types

Other

Identifiers

NCT03362255
2017-08-017

Details and patient eligibility

About

It is reported that optic nerve sheath diameter increases when higher volume of medication is injected during epidural anesthesia.

This study is designed to compare the optic nerve sheath diameter using 10cc of nomal saline of different speed (3cc/sec vs. 1cc/sec).

Full description

It is known that insufficient intraoperative or postoperative management can lengthen the hospital stay with unwanted complications. Therefore, active and proper management using continuous thoracic epidural catheterization is suggested good option to prevent such potential complication.

According to previous study, injection of different volume of local anesthetics (1.0 ml/kg vs. 1.5 ml/kg) during caudal anesthesia, high volume of local anesthetics resulted in significant increase of intracranial pressure (ICP). Increase of ICP can reduce regional cerebral flow and oxygen saturation causing the safety of patients. In addition, increase of ICP can result in headache, syncope, and transient loss of visual acuity.

Although it is very invasive method, ICP can be measured directly at the brain parenchyme. Among methods to measure the ICP indirectly, measurement of optic nerve sheath diameter using ultrasound is known to reflect the degree of ICP. It is reported that optic nerve sheath diameter increases when higher volume of medication is injected during epidural anesthesia.

This study is designed to compare the optic nerve sheath diameter using 10cc of nomal saline of different speed (3cc/sec vs. 1cc/sec).

Enrollment

40 patients

Sex

All

Ages

20 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • lung cancer
  • liver cancer
  • stomach cancer
  • pancreas cancer

Exclusion criteria

  • coagulopathy
  • infection
  • previous spine fusion at thoracic level
  • previous brain surgery

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

40 participants in 2 patient groups

Rapid speed of injection
Active Comparator group
Description:
Rapid speed of injection (3cc/sec) during thoracic epidurography thoracic epidural catheterization
Treatment:
Other: thoracic epidural catheterization
Slow speed of injection
Active Comparator group
Description:
Slow speed of injection (1cc/sec) during thoracic epidurography thoracic epidural catheterization
Treatment:
Other: thoracic epidural catheterization

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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