Measurement of Substance P in Saliva of Low Back Pain Patients

Kovacs Foundation

Status: Terminated

Conditions: Low Back Pain

Treatments: Other: The taking of a saliva sample from each subject.

Study type: Interventional

Funder types: Other

Identifiers

NCT00735735

FK 26

Details and patient eligibility

About

The purpose of this study is to compare the levels of Substance P in saliva, in patients with severe chronic low back pain and in subjects without it. In addition, to explore a possible cutoff point, in order to define normal and pathological levels of Substance P in saliva. The ultimate objective would be to design a measurement method for use in routine clinical practice.

Enrollment: 40 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients referred to the Kovacs Back Pain Unit in Palma de Mallorca for chronic low back pain
• A pain level of 6 or greater on the PI-NRS scale (0=no pain, 10= worst pain possible)
• Seen at the Unit between 9 and 13 hours (due to the circadian rhythm of Substance P in saliva and to avoid great variability in the results)

For healthy subjects:

• Volunteers with no pain (anywhere)
• That in the past year have had no more than 40 days with pain, and no episode of more than 7 days of continuous pain.

Exclusion criteria

• Subjects with pain that is additional to or different from chronic low back pain