Measurement of the Cerebral Saturation for Assessment of Safety of Epidural Anaesthesia During Abdominal Surgery

Jagiellonian University

Status: Completed

Conditions: Surgical Complications From General Anesthesia; Cerebral Ischemia; Anesthesia; Reaction

Study type: Observational

Funder types: Other

Identifiers

NCT03161275

K/ZDS/002839

Details and patient eligibility

About

Subsequent and non-randomised patients, adult patients qualified for major abdominal surgeries were enrolled

Enrollment: 101 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• scheduled for major abdominal surgery for at least 2 h
• under general anesthesia
• American Society of Anesthesiologists（ASA）physical status : II ~ III
• Age > 18

Exclusion criteria

• refuse of patients
• patient with results of test: "The Mini Mental State Examination"" less then 24 before operation
• neurosurgery history of patients

Trial design

101 participants in 2 patient groups

nirs

Description:

The cerebral oxymetry saturation was monitored continuously, using a non-invasive method. The cerebral saturation was monitored intraoperatively with near infrared spectroscopy (INVOS 4100; Somanetics Inc, Troy, MI). Data acquired from the device were automatically and continuously recorded in 10-second intervals throughout the anaesthesia. A lead for the cerebral saturation monitoring was placed on degreased skin on the patient's forehead, on the right side, some 1 cm over the eyebrow. The baseline value was determined before induction of anaesthesia. The following criteria were accepted as significant reduction of the cerebral oxygenation (saturation) value: reduction of the cerebral oxymetry by over 25% in relation to the baseline; the absolute value of cerebral oxymetry below 50%.

cognitive function

Description:

Upon the day preceding the actual surgery, and again at 5 days after the surgery, the Mini Mental State Examination test was completed, with a view to assessing the chang-es in the patients' cognitive function. The difference between score in Mini Mental State Examination higher than 2 points defined a diagnosis of cognitive dysfunction.