Measurement of the Cervix During Pregnancy According to Age of Conization (MesCon)

Centre Hospitalier Universitaire, Amiens

Status: Unknown

Conditions: Cervix; Pregnancy

Treatments: Other: Previous conization; Other: no previous conization

Study type: Observational

Funder types: Other

Identifiers

NCT03472066

PI2017_843_0021

Details and patient eligibility

About

Treatment of precancerous lesions of the cervix by conization has been shown to increase the risk of premature delivery and premature rupture of the membranes. It has now been clearly established that the cervix is a growing organ during adolescence and early adulthood, It has been hypothetized that cervical conization during the growth phase reduced its growth potential, and induced shorter cervix during the upcoming pregnancy. No studies have been conducted investigating the age at which conization no longer had an impact on cervical size during pregnancy. This will help to identify the age at conisation below which patients will be identified as being at risk event, and thus offer increased monitoring and possibly prophylactic management by programmed strapping. We propose to measure the length of the cervix of pregnant patients who have benefited from conization, which is currently recommended by the Collège National des Gynécologues Obstetriciens Français .In addition, the investigators will use a control group consisting of non-con conical, parity-matched pregnant patients in whom a cervical measurement will also be performed.

Enrollment: 180 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patient referred since January 2008 with pregnancy between 2008 and 2017
2. Pregnancy after conisation
3. Cervix size between 21 and 24 SA before any obstetric event
4. Control group: parity matching, asymptomatic patients

Exclusion criteria

1. Threat of late miscarriage,
2. Premature rupture of membranes before cervical echography,
3. Other pregnancies after study of 1st pregnancy after conisation,
4. No measurement of the conization specimen,
5. Lost to follow-up,
6. Age <18
7. Twin Pregnancies
8. Patient under guardianship

Trial design

180 participants in 2 patient groups

a group of women who have been conized

Description:

Previous conization

Treatment:

Other: Previous conization

control group with asymptomatic patients

Description:

on routine second trim no previous conization

Treatment:

Other: no previous conization