Measurement of the Skin Sympathetic Nerve Activity

Seoul National University

Status: Completed

Conditions: Skin Sympathetic Nerve Activity During General Anesthesia in Patients Undergoing Breast Cancer Surgery

Treatments: Drug: Rocuronium

Study type: Interventional

Funder types: Other

Identifiers

NCT03658057

SKNA pilot

Details and patient eligibility

About

Sympathetic nerve activity can be measured transcutaneously in awake patients by computer-based filtering of raw signal obtained via skin leads attached on the chest. Electrocardiogram can be removed by applying a high-pass filter setting of 150 Hz. Electromyogram can be filtered by applying a high-pass filter setting of 500 Hz or a band-pass filter setting of 500-1000 Hz.

However, it is not known whether the skin sympathetic nerve activity (SKNA) can be measured in anesthetized and/or paralyzed patients. Therefore, we planned this pilot study to observe whether the SKNA can be obtained in these patients. If the SKNA ca be observed, it will be presented in milivolt (uV).

Enrollment: 20 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients scheduled to undergo resection of breast cancer under general anesthesia after insertion of laryngeal mask airway

Exclusion criteria

• Autonomic nervous system disease
• Medication acting on the autonomic nervous system
• Refuse to participate

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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20 participants in 2 patient groups

ROC

Active Comparator group

Description:

Neuromuscular blockade is performed in the ROC group by administering rocuronium 0.4\~0.8mg/kg before the insertion of laryngeal airway.

Treatment:

Drug: Rocuronium

Control

No Intervention group

Description:

Neuromuscular blockade is not performed.