Measurement of Urinary Catabolites of PACs as Biomarkers of Consumption of Cranberry Extracts (CUPACS)

Laval University

Status and phase: Completed; Phase 1

Conditions: Urinary Tract Infections

Treatments: Dietary Supplement: Cranberry extract

Study type: Interventional

Funder types: Other

Identifiers

NCT02087735

PACS-2013-SD

Details and patient eligibility

About

The purpose of this cross over pilot study is to investigate the urinary catabolites of Proanthocyanidines (PACs) as biomarkers of cranberry extracts in healthy young women.

Enrollment: 15 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy women.
• 18 to 40 years.

Exclusion criteria

• No internet access.
• No refrigerator access during the 9 hours of sample collection.
• Women who had or expect to take antibiotic.
• Women who had or expect to take cranberries, blueberries or bilberries in the form of berries, juice or extracts.
• Women who had or expect to take dark chocolate.
• Women who had personal history of acute or chronic renal failure.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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15 participants in 3 patient groups, including a placebo group

cranberry extract 1

Experimental group

Description:

One capsule with a proanthocyanidin standardized cranberry extract of 36 mg and one capsule of placebo cranberry extract.

Treatment:

Dietary Supplement: Cranberry extract

cranberry extract 2.

Experimental group

Description:

Two capsules with a proanthocyanidin standardized cranberry extract of 36 mg.

Treatment:

Dietary Supplement: Cranberry extract

cranberry extract 3.

Placebo Comparator group

Description:

Two capsules with a proanthocyanidin standardized cranberry extract of 2 mg.

Treatment:

Dietary Supplement: Cranberry extract