Measurement of Viral Load Reduction in the Oral Cavity After a Regimental Use of OC Toothpaste Products

Colgate-Palmolive

Status and phase: Completed; Phase 3

Conditions: Covid19

Treatments: Drug: Tom's Botanically Bright Peppermint; Drug: Colgate Total Clean Mint

Study type: Interventional

Funder types: Industry

Identifiers

NCT04864925

EXT-SARS2-COV2-OC-RUT-CD

Details and patient eligibility

About

SARS COVID 2 has caused a pandemic of proportions unparalleled in the past 100 years. The virus has an uncanny ability for transmission and as such has been difficult to control. The spread of the virus has affected everything from education, business, politics and survival. While the investigators have learned a great deal in the last 9 months they still face an uncertain day to day existence. Health care workers are particularly vulnerable to transmission of this virus because of their close contact with patients. Moreover, dentists are particularly vulnerable because the virus is spread via aerosols which are generated quite easily in the dental office putting dentists and their associates at risk. The oral cavity appears to be a likely domain for viral carriage particularly since both taste and smell are hallmark effects of the virus. With these issues at hand it will be of great advantage to have a simple routine oral hygiene method in the effort to reduce the oral viral load. There is some reason to expect that oral hygiene procedures with known anti-microbial effects could have some use in our efforts to reduce or control the oral viral load. With this issue in mind investigators feel that stannous fluoride could modify the virus in such a manner as to effectively reduce the oral viral load.

Full description

Study will measure reduction of SARS-CoV-2 levels in the oral cavity after brushing for up to an hour. Subject sampling will occur at baseline, 15 min, 30 min, and 60 min

Enrollment: 46 patients

Sex: All

Ages: 18 to 64 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Enrolled subjects between the ages of 18-64 and have tested positive for Covid19.

Exclusion criteria

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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46 participants in 2 patient groups

Colgate Total Clean Mint

Experimental group

Description:

Brush with toothpaste for a minimum of 2 minutes

Treatment:

Drug: Colgate Total Clean Mint

Tom's Botanically Bright Peppermint

Active Comparator group

Description:

Brush with toothpaste for a minimum of 2 minutes

Treatment:

Drug: Tom's Botanically Bright Peppermint