Measurement Skin Temperature During Pulsed Laser Exposure

University of California Irvine (UCI)

Status and phase: Completed; Phase 2

Conditions: Port-Wine Stain

Treatments: Procedure: cooling spray during laser treatment

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00540917

19992250

Details and patient eligibility

About

Lasers are the treatment modality of choice for Port Wine Stain birthmarks.The epidermis is not totally spared due to partial absorption of energy therein by melanin that presents an optical barrier through which the light must pass to reach the underlying blood vessels. Absorption of laser energy by melanin causes localized heating in the epidermis, which may, if not controlled, produce permanent complications such as hypertrophic scarring or dyspigmentation.

Full description

The researchers want to establish a correlation between non-invasive skin temperature measurements and the minimum laser energy during skin laser treatment using cryogen spray cooling.

This study would eliminate the need for test pulses to estimate the safe and acceptable radiant exposure prior to laser treatment.

Enrollment: 118 patients

Sex: All

Ages: 7 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 7 years of age and older with diagnosis of port wine stain birthmark
• 18 years of age and older with no port wine stain
• non-pregnant women
• apparent good health

Exclusion criteria

• age less than 7 years old
• pregnant women
• history of photodermatoses or skin cancer
• current use of photosensitizing drugs

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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118 participants in 1 patient group

cooling spray

Experimental group

Description:

cooling spray during laser treatment

Treatment:

Procedure: cooling spray during laser treatment