Measurements to Assess Severity of Epicardial Stenoses (MASES)

University of Cincinnati

Status: Terminated

Conditions: Coronary Artery Disease

Treatments: Device: FFR/CFR and IVUS

Study type: Interventional

Funder types: Other

Identifiers

NCT00760630

UCIRB08031108

Details and patient eligibility

About

Newly developed diagnostic parameters have potential to differentiate between epicardial disease and microvascular dysfunction with the help of anatomical details and physiological endpoints and can be used in present clinical settings.

Full description

The pressure drop coefficient (CDP) is a functional index based on hyperemic dp and u measurements. The lesion flow coefficient (LFC) combines the functional index CDP with an atomic measure (percentage area stenosis) as a single parameter.

Enrollment: 10 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Abnormal Myocardial stress perfusion (SPECT) LV EF > 25%

Exclusion criteria

• LV < or + to 25% Serum Creatinine > 2.5 gm/dL Type II HIT Significant co-morbidities Pregnant women

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

CDP LFC

Experimental group

Description:

all patients will have this calculation based upon diagnostic parameters with IVUS and FFR and/or CFR

Treatment:

Device: FFR/CFR and IVUS