Measures of Pain Relevant to Knee Osteoarthritis

University of Nottingham

Status: Completed

Conditions: Osteoarthritis of the Knee

Treatments: Other: Questionnaires

Study type: Observational

Funder types: Other

Identifiers

NCT01310257

9227 (Registry Identifier)

10052 (Registry Identifier)

Details and patient eligibility

About

The aim is to improve understanding of the assessment of pain experience in patients with osteoarthritis (OA) of the knee. The current study will be divided into two parts. In Study 1, the investigators will analyse existing questionnaires relevant to the mechanisms and therapeutic targets of knee OA to establish discrete dimensions that discriminate between the different mechanisms of pain. On the basis of this analysis, the investigators will refine the questionnaires to maximise their sensitivity to knee OA. In Study 2, the investigators will seek to confirm the factor structure identified in the questionnaires in Study 1 and explore potential mediator and moderator variables between pain and quality of life using the refined measures. The investigators will also evaluate Quantitative Sensory Testing as a predictor of OA knee pain.

Enrollment: 448 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants in Study 1 will have OA of the knee defined and scored radiologically and will report knee pain. Participants in Study 2 will also have OA of the knee, but a clinical diagnosis will suffice.

Exclusion criteria

• Inability to speak or understand English
• Under the age of 18 years old
• knee joint surgery within three months prior to participation
• Diagnosed Rheumatoid Arthritis, Psoriatic Arthritis, Gout or any other inflammatory arthritis disorder
• The participants in Study 2 will also be excluded if they participated in Study 1

Trial design

448 participants in 1 patient group

Knee osteoarthritis

Description:

Patients will have osteoarthritis (OA) of the knee defined and scored radiologically in Study 1. Patients in Study 2 will also have OA of the knee, but a clinical diagnosis will suffice. All patients will report knee pain.

Treatment:

Other: Questionnaires