Measuring Cortisol Levels in Persons With Parkinson's (PD) (CORT-PD)

Oregon Health & Science University (OHSU)

Status: Completed

Conditions: Huntington Disease; Parkinson Disease

Treatments: Other: No Intervention - Observational Study

Study type: Observational

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT02727270

5338

3794 (Other Identifier)

7186 (Other Identifier)

4546 (Other Identifier)

15183

Details and patient eligibility

About

The objective of this study is to evaluate the cortisol awakening response with persons with Parkinsons Disease (PD), Huntingtons Disease (HD), and controls. These data are desired so experience can be gained with measuring stress levels subjectively and objectively in persons with PD, HD, and controls.

Full description

Telephone consent will be obtained.

Participants will collect saliva at twelve time points - four times a day for three days.

Visits will be conducted virtually (over the internet).

The virtual visit is to assess Parkinson's or Huntington's disease status, stress, mood, and quality of life.

Enrollment: 131 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Group (3) Inclusion:

• No significant neurological disorder
• PSS score of greater than or equal to 13.

Group (5) Inclusion:

• HD diagnosis or HD gene carrier
• a Perceived Stress Scale (PSS) score higher than or equal to 13.

Group (6) Inclusion:

• HD diagnosis or HD gene carrier
• PSS score lower than 13

Group (7) Inclusion:

• PD diagnosis
• Prior completion of the study.

Exclusion criteria

• The use of medications known to effect cortisol levels (estrogen, synthetic glucocorticoids, androgens, phenytoin, spironolactone, prednisone, prednisolone, and hydrocortisone).

Trial design

131 participants in 7 patient groups

Parkinson's - High Stress *FULL NOT RECRUITING

Description:

Parkinson's disease patients with self-reported high strain/stress.

Treatment:

Other: No Intervention - Observational Study

Parkinson's - Low Stress *FULL NOT RECRUITING

Description:

Parkinson's disease patients with self-reported low strain/stress.

Treatment:

Other: No Intervention - Observational Study

Controls - High Stress *FULL NOT RECRUITING

Description:

Healthy controls (no neurological disease) with self-reported high strain/stress.

Treatment:

Other: No Intervention - Observational Study

Controls - Low Stress *FULL NOT RECRUITING

Description:

Healthy controls (no neurological disease) with self-reported low strain/stress.

Treatment:

Other: No Intervention - Observational Study

Huntington's - High Stress *FULL NOT RECRUITING

Description:

Huntington's disease patients and/or Huntington's disease gene carriers with self-reported high strain/stress.

Treatment:

Other: No Intervention - Observational Study

Huntington's - Low Stress *FULL NOT RECRUITING

Description:

Huntington's disease patients and/or Huntington's disease gene carriers with self-reported low strain/stress.

Treatment:

Other: No Intervention - Observational Study

Parkinson's Disease - ReEnrollment (COVID-19) *FULL NOT RECRUITING

Description:

Parkinson's disease patients that had previously completed the study.

Treatment:

Other: No Intervention - Observational Study