Measuring Erythrocyte Iron Incorporation From Different Dosing Regimens in Anemic Women

F

Federal Institute of Technology (ETH) Zurich

Status

Completed

Conditions

Iron Deficiency Anemia

Treatments

Other: Iron stable isotope labeled iron(II) sulfate

Study type

Observational

Funder types

Other

Identifiers

NCT03623997
FeSupp_Anemia

Details and patient eligibility

About

Iron-deficient anaemic subjects are likely to benefit most from oral iron supplements, but supplementation schedules vary widely in clinical practice, absorption is low and compliance is poor due to mild gastrointestinal side effects. The investigators will compare iron absorption from labeled oral iron doses of 100mg and 200mg administered either on two consecutive days or on alternate days in young anemic women.

Enrollment

20 patients

Sex

Female

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Ferritin <15 µg/L
  • Hb 8-11.9 g/dl
  • BMI 18.5-24.9 kg/m2
  • Body weight <70 kg

Exclusion criteria

  • Severe anemia (Hb <8 g/dl)
  • Elevated CRP >5.0 mg/L
  • Chronic disease
  • Long-term medication, except contraception
  • Consumption of Mineral and Vitamin supplements within the study period
  • Therapeutic iron infusion over the past 6 months
  • Pregnancy or breastfeeding
  • Smoking

Trial design

20 participants in 1 patient group

Stable isotope labeled iron II sulfate
Description:
All subjects will go through two iron absorption study cycles. In one cycle they get 100mg oral iron labeled with stable isotopes on two consecutive and on one alternate day and in another cycle they get 200mg oral iron labeled with stable isotopes on two consecutive and on one alternate day. Half of the subjects start with the 100mg cycle whereas the other half starts with the 200mg cycle.
Treatment:
Other: Iron stable isotope labeled iron(II) sulfate

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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