Measuring Response to Depression Treatment

Dr. D McIntosh & Dr. K Kjernisted Clinical Research Inc.

Status: Unknown

Conditions: Depression

Treatments: Other: Treatment-as-usual

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT00924183

D1443L00014

Details and patient eligibility

About

The primary goal of this study is to compare a new symptoms rating questionnaire, called the Vancouver Semi-Structured Interview for Depression (V-SID), to the traditionally used questionnaires. The investigators predict that the V-SID will be more sensitive to patients' improvement than are traditional questionnaires.

Full description

Depression is sometimes associated with difficulties in thinking skills. Recent evidence suggests that in those people who have thinking difficulties, effective treatment and improvement of depression can also result in improved thinking skills. Therefore, a test of thinking skills is included in this study.

This study will also evaluate three other potential indicators of treatment response: cortisol, cytokines, and grip strength.

Enrollment: 70 estimated patients

Sex: All

Ages: 19 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Major depressive episode, diagnosed using the Mini-International Neuropsychiatric Interview (MINI)
• Depression not currently effectively treated
• Age 19 to 65 years

Exclusion criteria

• Co-morbid Axis I disorders (co-morbid anxiety symptoms, including generalized anxiety or panic attacks, are not exclusionary if they are present in the context of a primary mood disorder)

Trial design

70 participants in 1 patient group

Treatment-as-usual

Description:

All patients will receive treatment as usual: antidepressant medication and/or cognitive behavioral therapy (CBT). Patients' results will be compare to their own baseline measurements.

Treatment:

Other: Treatment-as-usual