Measuring the Impact of Real Time fMRI Neurofeedback in Borderline Personality Disorder

Yale University

Status: Completed

Conditions: Borderline Personality Disorder

Treatments: Behavioral: real time fMRI neurofeedback

Study type: Interventional

Funder types: Other

Identifiers

NCT04306341

2000026750

Details and patient eligibility

About

This study will test the impacts of real time fMRI neurofeedback in patients with Borderline Personality Disorder. This is a pilot study in a small number of people enrolled in clinical programs at Yale New Haven Hospital.

Enrollment: 3 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. enrolled in YNHH DBT-IOP
2. must meet specific clinical criteria
3. Inclusion in Experimental group requires participants meet standard safety and quality control requirements for MR scanning
4. For female participants, not pregnant and willing to use a reliable method of contraception during the study

Exclusion criteria

1. IQ<70
2. vision problem not able to be corrected to normal range
3. medication changes w/in one month
4. Lifetime hx of schizophrenia, schizoaffective d/o, bipolar I disorder.
5. illicit substance use within 7 days of MRI scans
6. taking scheduled opiates
7. taking scheduled benzodiazepines
8. taking scheduled anti-histamines
9. history of seizures
10. significant current or past neurologic illness
11. BMI < 16.5

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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3 participants in 2 patient groups

Experimental

Experimental group

Description:

Neurofeedback in conjunction with Dialectical Behavior Therapy

Treatment:

Behavioral: real time fMRI neurofeedback

Control

No Intervention group

Description:

Dialectical Behavior Therapy (treatment as usual)