Measuring the Plasma Clearance of Iohexol to Estimate Glomerular Filtration Rate in Intensive Care Unit Patients: Preliminary Feasibility Study (IoxRea)

Regional University Hospital Center (CHRU)

Status and phase

Completed

Phase 3

Conditions

Acute Circulatory Failure

Treatments

Drug: Iohexol

Study type

Interventional

Funder types

Other

Identifiers

NCT02050269

2013-003936-65 (EudraCT Number)

2013-R49 (Other Identifier)

PHAO13-SE / IoxRea

131229A-11 (Other Identifier)

Details and patient eligibility

About

The objective of this study is to assess the feasibility of estimating the clearance of iohexol as an indirect measure of glomerular filtration rate in patients with unstable renal function in the intensive care unit through analysis of rich iohexol plasma kinetics.

Enrollment

100 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥ 18 years
Patient admitted to intensive care for less than 12 hours
Acute circulatory failure
Patient carrying an arterial catheter
Informed consent obtained
Affiliated to social security system

Exclusion criteria

Administration of iohexol the week before intensive care admission
Administration of iohexol expected within 24 hours of study entry
Known history of cutaneous immediate or delayed allergic reaction to the injection of the product
Indication for albumin transfusion within 24 hours of potential inclusion in the study
Pregnancy or breastfeeding in progress
Patient under guardianship or judicial protection known at the time of inclusion
Withdrawal of consent
Administration of iohexol outside the study within 24 hours after administration of iohexol in the context of the study
Administration of intravenous albumin in the 24 hours following administration of iohexol in the context of the study