Mechanical Bowel Preparation Versus no Bowel Preparation for Esophageal Cancer Surgery

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Completed

Conditions: Esophageal Cancer

Treatments: Procedure: No MBP

Study type: Interventional

Funder types: Other

Identifiers

NCT05523960

NCC2020C-511

Details and patient eligibility

About

The study type was designed as a prospective multicenter randomized controlled study. The patients will be divided into intervention group and control group, 281 patients were needed for each group and 562 patients would be needed totally to show this difference. Due to a possible loss of 14%, the final sample size was calculated to be 652 patients. The intervention group will not implement mechanical bowel preparation(MBP) before surgery; the control group will receive routine preoperative MBP for oral administration of compound polyethylene glycol electrolyte powder and fasting water. Perioperative complications, intestinal recovery speed and quality of life will be investigated between the two groups.

Full description

Patients allocated to MBP will be instructed by the study nurse to prepare their bowel mechanically by drinking 3~4L of polyethylene glycol (Polyethylene Glycol Electrolytes Powder 68.56g; Shenzhen, China) with water before 6pm in the evening the day before the surgery. Patients allocated to NBP were instructed to not prepare the bowel. The receipt of the allocated intervention will be controlled by study nurse asking the patients on the morning of the surgery whether they had acted as instructed by the allocation. This information will be also concealed from treating physicians and surgeons, data collectors, and data analysts, until the primary and secondary outcomes were analyzed. All patients will follow the ERAS protocol. Prophylactic intravenous antibiotics (cephamycin 1000mg) will be given to all patients 30 minutes before skin incision. The prophylactic intravenous antibiotics will re-administered if the surgery lasted longer than 3h from the first antibiotic dose. Surgical skin preparation will involve taking a bath well the night before operation without shaving the hair. Just before skin incision, the area will then washed three times with denatured 80% alcohol to left to dry.

Enrollment: 652 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who were scheduled for esophageal cancer resection in participating centers were eligible for inclusion.

Exclusion criteria

• need for emergency surgery;
• previous chronic constipation or diarrhea;
• previous abdominal surgery; need for colonic reconstruction;
• other indications for mechanical preparation or contraindications;
• allergy to drugs used in the trial (polyethylene glycol)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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652 participants in 2 patient groups

NBP group

Experimental group

Description:

Patients allocated to NBP were instructed to not prepare the bowel.

Treatment:

Procedure: No MBP

MBP group

Other group

Description:

Patients allocated to MBP were instructed by the study nurse to prepare their bowel mechanically by drinking 3\~4L of polyethylene glycol (Polyethylene Glycol Electrolytes Powder 68.56g; Shenzhen, China) with water before 6pm in the evening the day before the surgery.

Treatment:

Procedure: No MBP