Mechanical Ventilation in Severe Brain Injury: The Effect of Positive End Expiratory Pressure on Intracranial Pressure

Beth Israel Lahey Health logo

Beth Israel Lahey Health

Status

Terminated

Conditions

Brain Injuries
Respiratory Failure
Lung Injury
Positive-Pressure Respiration, Intrinsic
Critical Illness
Intracranial Hypertension

Treatments

Other: PEEP titrated mechanical ventilation

Study type

Interventional

Funder types

Other

Identifiers

NCT02680704
2015P000089

Details and patient eligibility

About

The purpose of this study is to collect physiologic data from patients with severe brain injury who require mechanical ventilation in order to describe the impact of ventilation, specifically positive end expiratory pressure (PEEP), on intracranial pressure (ICP).

Enrollment

4 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients with severe brain injury (GCS 8 or less)
  • Receiving mechanical ventilation
  • Receiving intracranial pressure monitoring

Exclusion criteria

  • Esophageal varices
  • Esophageal trauma
  • Recent esophageal surgery
  • Coagulopathy (Platelets < 80k or INR> 2 )
  • Other contraindication for esophageal manometry
  • Already receiving PEEP > 15 cmH2O at enrollment
  • Intracranial hypertension (defined as ICP > 20 mmHg)
  • Decompressive hemi-craniectomy

Trial design

Primary purpose

Other

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

4 participants in 1 patient group

PEEP Titration Arm
Other group
Description:
PEEP titrated mechanical ventilation
Treatment:
Other: PEEP titrated mechanical ventilation

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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