Mechanical Ventilation With and Without Postural Drainage in Burn Patients With ARDS

R

Riphah International University

Status

Completed

Conditions

Burns (Physical Finding)

Treatments

Other: Mechanical Ventilation with Postural drainage
Other: Mechanical Ventilation

Study type

Interventional

Funder types

Other

Identifiers

NCT05321888
REC/RCR & AHS/220310

Details and patient eligibility

About

Inhalation injury become a more common cause of death in burn patients but alone the smoke injury has low mortality rate. It is reported that a combination of smoke injury with cutaneous burn increases the mortality rate and predispose to Acute Respiratory Distress Syndrome. This experimental study aims to report the benefits of postural drainage on the respiratory system in burn patients. This study will determine the effects of postural drainage on oxygen saturation, airway clearance in burn patients with Acute Respiratory Distress Syndrome by comparing mechanical ventilation with and without the application of postural drainage. A randomized clinical trial will be conducted in the data and will be collected from the ICU of Jinnah Burn \& Reconstructive Surgery Centre and Shafique Aziz Free Burn Centre through consecutive sampling through technique on 50 patients which will be allocated through sealed opaque enveloped into Group A and Group B. Pre and post treatment value of oxygenation and other variables for both group will be recorded by using APACHE II. Group A will be treated by postural drainage and mechanical ventilation for two consecutive days. Similarly, Group B will be treated by mechanical ventilation only. Data will be analyzed using SPSS software 25. After assessing the normality of data by the Shapiro-Wilk test, it will be decided either parametric or non-parametric tests will be used within a group or between two groups.

Enrollment

50 patients

Sex

All

Ages

10 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients of both gender male and female are included.
  • Patient age should be between 10-40 years
  • Patients that are on mechanical ventilation
  • Patients with inhalation injury
  • Patients undergo mechanical ventilation for >48 hours

Exclusion criteria

  • Patient with no past medical history of Lung disease
  • Subject with more than 80% of burn according to Rule of Nine
  • Patients with cardiac instability such as recent Myocardial infarction, Unstable angina and severe hypotension and hypertension

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

50 participants in 2 patient groups

Mechanical Ventilation
Active Comparator group
Description:
Mechanical Ventilation
Treatment:
Other: Mechanical Ventilation
Mechanical Ventilation with Postural drainage
Experimental group
Description:
Mechanical Ventilation with Postural drainage
Treatment:
Other: Mechanical Ventilation with Postural drainage

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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