Mechanism-based Choice of Therapy for Pain: Can Successful Prevention of Migraine be Coupled to a Psychophysical Pain Modulation Profile?

Rambam Health Care Campus

Status: Completed

Conditions: Migraine

Treatments: Drug: Amitriptyline; Drug: Topiramate

Study type: Interventional

Funder types: Other

Identifiers

NCT01161017

Migraine06CTIL

Details and patient eligibility

About

Mechanism-based choice of therapy for pain:

Can successful prevention of migraine be coupled to a psychophysical pain modulation profile?

Enrollment: 67 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• female and male migraine patients with a number of month attacks ≥ 4,
• age 18-75,
• without any other chronic pain.

Exclusion criteria

• any migraine preventive treatment for last 6 month & psychiatric,
• language or cognitive dysfunction precluding use of psychophysics.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

67 participants in 2 patient groups

1 Amitriptyline.

Active Comparator group

Description:

Amitriptyline

Treatment:

Drug: Amitriptyline

2 Topiramate

Active Comparator group

Description:

Topiramate

Treatment:

Drug: Topiramate