Mechanism of Action of Vichy Catalan Water

Higher Council for Scientific Research (CSIC)

Status: Completed

Conditions: Cardiovascular Diseases

Treatments: Dietary Supplement: Bicarbonated mineral water; Dietary Supplement: Mineral water low in mineral content (control)

Study type: Interventional

Funder types: Other

Identifiers

NCT01334840

BW-09

Details and patient eligibility

About

Water consumption is essential to maintain hydration and good health. Sodium-bicarbonated mineral waters are reported to have beneficial digestive and hypocholesterolemic properties. The aim of this study was to investigate the effects of the consumption of a sodium-bicarbonated mineral water (BW) with or without a meal, compared to a low mineral content water as a control water (CW), on postprandial serum triacylglycerols (TAG), cholecystokinin (CCK), and gallbladder volume.

Enrollment: 21 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adult (>18 and <40 years)
• BMI >18 and <30 kg/m2

Exclusion criteria

• Age <18 and > 40 years
• TAG > 250 mg/dL (2.82 mmol/L)
• Being a usual consumer of carbonic mineral water
• Obesity
• Diabetes
• Hypertension or digestive, liver and renal disease
• Biliary obstruction
• Eating disorders
• Being under medication that could affect lipid metabolism
• Consumption of functional foods that could affect lipid metabolism (food containing n-3 fatty acids or phytosterols)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

21 participants in 4 patient groups

BW

Experimental group

Description:

Bicarbonated mineral water without meal

Treatment:

Dietary Supplement: Bicarbonated mineral water

BW with meal

Experimental group

Description:

Bicarbonated mineral water with meal

Treatment:

Dietary Supplement: Bicarbonated mineral water

CW

Active Comparator group

Description:

Mineral water low in mineral content (control) without meal

Treatment:

Dietary Supplement: Mineral water low in mineral content (control)

CW with meal

Active Comparator group

Description:

Mineral water low in mineral content (control) with a meal

Treatment:

Dietary Supplement: Mineral water low in mineral content (control)