Mechanisms Behind Antidiabetic Effects by Gastric By-pass

Karolinska Institute

Status: Completed

Conditions: Diabetes Mellitus Typ 2 and Obesity

Treatments: Dietary Supplement: Modifast; Dietary Supplement: Normal diet

Study type: Interventional

Funder types: Other

Identifiers

NCT01708096

2009/931-31/2

Details and patient eligibility

About

The aim of the study is to develop new strategies in treatment of continuous increasing number of patients with type 2 diabetes by understanding how bariatric surgery cures or improves this condition.

Enrollment: 15 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diabetes typ 2
• 18-70 years
• BMI > 35 kg/m2
• Treated with oral antidiabetic agents and/or insulin
• laparoscopic surgery

Exclusion criteria

• Pharmacological treatment (other then above) witch could affect glucose metabolism
• open surgery

Trial design

15 participants in 2 patient groups, including a placebo group

Modifast

Active Comparator group

Description:

treated with VLD Modifast 1000 kcal/day in 2 weeks before gastric by-pass,

Treatment:

Dietary Supplement: Modifast

Normal diet

Placebo Comparator group

Description:

normal diet 2 weeks before gastric by-pass surgery

Treatment:

Dietary Supplement: Normal diet