Mechanisms for Laser-Induced Rejuvenation

Wright State University

Status: Not yet enrolling

Conditions: Skin Cancer

Treatments: Device: Fractionated Laser Resurfacing

Study type: Interventional

Funder types: Other

Identifiers

NCT06489301

2023-312

Details and patient eligibility

About

It has shown that laser wounding of geriatric skin protects it against skin cancer. The purpose of this study is to determine the origin of cells called fibroblasts which are present after treatment with Fractionated Laser Resurfacing (FLR). These cells restore a youth-like ultraviolet B (UVB) response, but where they come from is currently unknown. The study recruits subjects who are scheduled to undergo abdominoplasties to investigate the origin of those cells stimulated by laser treatment.

Enrollment: 12 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult males and females 18 and older
• Able to comprehend procedures and risks
• Planning to undergo abdominoplasty surgery
• Minimum amount of skin to be removed is 50 x 20cm

Exclusion criteria

• Medical history of not well-controlled diabetes. This is defined as a subject who needs high doses of insulin, recent history of hospitalization for diabetes-related complications, or poor wound health as evidenced by diabetic ulcers. Subjects who have been deemed healthy enough for abdominoplasty surgery would tend to suggest that their diabetes should not be an issue. However, if the subjects have diabetic complications as outlined above, they could affect the wound healing which is the object of this protocol so they would be excluded.
• Pregnant or nursing
• History of pathologically abnormal wound healing such as keloidal scars
• Existing tattoos on the abdomen that are so extensive that they could interfere with the study

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

Fractionated Laser Resurfacing

Experimental group

Description:

At 14 days prior to scheduled surgery a 5x5cm square on the left abdomen within the region of skin to be excised and treated with fractionated laser resurfacing. Then at 7 days prior to scheduled surgery a 5 cm diameter circle on the right abdomen within the region of skin to be excised, at least 10 cm away from the square, is treated with fractionated laser resurfacing.

Treatment:

Device: Fractionated Laser Resurfacing