Mechanisms of Acute Kidney Injury in Severe Infections (PET-AKI)

Uppsala University Hospital

Status

Enrolling

Conditions

Positron Emission Tomography (PET)

AKI - Acute Kidney Injury

Sepsis

Treatments

Radiation: Positron emission tomography (PET)

Study type

Observational

Funder types

Other

Identifiers

NCT06372444

995725

Details and patient eligibility

About

Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography. For marked water will be used for renal perfusion and a newly developed PET tracer molecule (11C-GW457427) with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation. The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations.

Full description

To study renal perfusion and neutrophil-mediated inflammation 10 critically ill patients with sepsis and acute kidney injury (AKI) and 5 healthy volunteers as controls will be recruited and examined at one time with marked water followed by neutrophil elastase tracer. At the same time, a CT scan is performed for anatomy. Plasma levels of inflammatory mediators will be measured. Clinical data will be collected. The endpoints are changes in renal perfusion and increased presence of neutrophil elastase in the renal parenchyma.

Enrollment

15 estimated patients

Sex

All

Ages

30+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients with sepsis and AKI

> 30 years
At least AKI stage 1 according to KDIGO where the last plasma creatinine is measured within 24 hours of the examination

Healthy volunteers

> 30 years
No previously known kidney disease
Normal plasma creatinine value

Exclusion criteria

Chronic renal failure (CKD stage >3a) or dialysis
Instability in vital functions that makes PET-CT examination unsuitable
Claustrophobia or other reasons that make the patient unable to lie still during the examination.
Pregnancy and breastfeeding