Mechanisms of Anaphylaxis (ANAMEK)

Haukeland University Hospital

Status: Active, not recruiting

Conditions: Transfusion Reaction; Febrile Transfusion Reaction; Allergy; Anaphylaxis

Treatments: Diagnostic Test: Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)

Study type: Observational

Funder types: Other

Identifiers

NCT03182491

2016/1635

Details and patient eligibility

About

The purpose of this study is to explore different mechanisms for anaphylaxis and find novel biomarkers for this hypersensitivity syndrome. The study participants are patients with anaphylaxis, patients with mild allergic reactions, and patients with febrile transfusion reactions. The investigators will also include a group of healthy controls.

Enrollment: 40 estimated patients

Sex: All

Ages: 16 to 120 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

According to the specific cohort:

1. Diagnosis of anaphylaxis
2. Mild allergic reaction
3. Febrile transfusion reaction
4. Healthy, no known allergic disease

Exclusion criteria

Suspicion or diagnosed sepsis Children

Trial design

40 participants in 4 patient groups

Anaphylaxis

Treatment:

Diagnostic Test: Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)

Febrile transfusion reactions

Treatment:

Diagnostic Test: Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)

Mild allergic reactions

Treatment:

Diagnostic Test: Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)

Healthy controls

Treatment:

Diagnostic Test: Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)