Mechanisms of Change in Brief Treatment for Borderline Personality Disorder (BPDCHANGE)

Lausanne University Hospital (CHUV)

Status: Unknown

Conditions: Borderline Personality Disorder

Treatments: Behavioral: Good Psychiatric Management - Brief; Behavioral: treatment as usual

Study type: Interventional

Funder types: Other

Identifiers

NCT03717818

2017-02167

Details and patient eligibility

About

The present two-arm randomized controlled study aims at testing the effects (i.e., symptom reduction) and the underlying mechanisms of change associated with a brief psychiatric treatment (10 sessions over 4 months), compared with treatment as usual. Participants undergo assessments at four points (intake, 2 months, discharge and 12 month follow-up). In addition to symptom measures, all individuals undergo a two-step assessment for the potential mechanisms of change (i.e., emotion and socio-cognitive processing): a) behavioural and b) neurofunctional. We hypothesize that change in the mechanisms explains the treatment effects. The present study uses an innovative treatment of BPD and at the same time a sophisticated assessment procedure to demonstrate the critical role of psychobiological change in emotion and sociocognitive processing in brief treatments. It will help increase the effectiveness of initial treatment phase for BPD and help diminish the societal burden of disease related with BPD. This study is funded by the Swiss National Science Foundation (SNSF).

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Borderline Personality Disorder
• age between 18 and 35

Exclusion criteria

• non-mastery in French
• neurological disorders
• schizophrenia (according to DSM-5)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 2 patient groups, including a placebo group

Good Psychiatric Management-Brief

Experimental group

Treatment:

Behavioral: Good Psychiatric Management - Brief

Treatment as Usual-Brief

Placebo Comparator group

Treatment:

Behavioral: treatment as usual