Mechanisms of Chronic Kidney Disease (CKD)-Induced Foam Cell Formation
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About
There is currently little understanding of macrophage cholesterol homeostasis and foam cell formation across the spectrum of CKD. We hypothesize that an inverse relationship exist between the severity of CKD and processes underlying foam cell formation, and that the relationship becomes independent of serum lipoprotein levels as renal function declines. We propose to systematically examine scavenger receptors and cholesterol uptake as well as cholesterol transporters and efflux mechanisms in individuals with normal renal function, patients with moderate CKD. We further propose to determine if processed contributing to foam cell formation are related to the plasma lipid profile and if the relationship is modified by co-morbidities, such as diabetes, obesity, systemic inflammation which are common in this population and directly influence vascular integrity. These data will be critically important to understand when the abnormality starts and will provide crucial information.
Enrollment
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Inclusion criteria
Patients with moderate degree of CKD, or patients with advanced CKD or control subjects with intact kidney function
Male or female
All ethnic groups
≥ 18 years and have signed informed consent
Exclusion criteria
Pregnancy and current smoking
BMI > 45
Rheumatoid arthritis and systemic lupus erythematosus
History of active or chronic hepatitis B, history of active or chronic hepatitis C, human immunodeficiency virus (HIV)
For moderate CKD subjects: nephrotic syndrome
For control subjects: nephrotic syndrome, patients with estimated GFR < 60 mL/min/1.73 m^2, or proteinuria
Trial design
103 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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