Mechanisms of Diabetes Control After Weight Loss Surgery, Sub-study #1

St. Luke's-Roosevelt Hospital Center

Status: Withdrawn

Conditions: Gastric Banding; Gastric Bypass Surgery; Type 2 Diabetes

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT01930448

03-108

Details and patient eligibility

About

Gastric bypass (GBP) and laparoscopic adjustable banding (AGB) are common procedures that can result in significant weight loss and significantly improve type 2 diabetes in 40-80% of cases. The mechanism and time course of these changes have not been well studied and are poorly understood. The primary aim of this study is to investigate the potential weight-independent mechanisms of diabetes remission after GBP, by comparing GBP and AGB subjects after similar weight loss.

Full description

All participants will be tested before and then after 10 and 20-30% weight loss after either GBP or AGB surgery. Subjects will undergo an oral glucose tolerance test (OGTT) an isoglycemic intravenous glucose test (IVGT) to assess the incretin effect, a measure of insulin sensitivity by an intravenous insulin sensitivity test (IVGTT) and body composition measurements.

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• obese type 2 diabetes individuals scheduled to undergo bariatric surgery by either gastric banding or gastric bypass surgery

Trial design

0 participants in 2 patient groups

gastric bypass

Description:

Surgical group of obese patients with type 2 diabetes undergoing gastric bypass surgery

gastric banding

Description:

surgical group of obese patients with type 2 diabetes undergoing gastric banding