Mechanisms of Disease Severity in Multiple Sclerosis: an Integrative Multimodal Study (SEP-BIO-PROG)

Institut National de la Santé Et de la Recherche Médicale, France

Status

Active, not recruiting

Conditions

Multiple Sclerosis

Treatments

Other: Composite severity score calculation

Study type

Observational

Funder types

Other

Identifiers

NCT03369106

C16-114

2017-A01844-49 (Registry Identifier)

Details and patient eligibility

About

This study will identify a combination of disease severity markers (genetic, immunology, epigenetic, imaging) associated with disease severity and progression in a cohort of patients with multiple sclerosis.

Full description

The heterogeneity of multiple sclerosis evolution relies on several pathophysiological mechanisms including neuroinflammation, neurodegeneration and remyelination and repair mechanisms.

The study will identify markers of disease severity in a longitudinal cohort of patients with multiple sclerosis who are siblings (both siblings having multiple sclerosis) including: biological markers (genetic, immunological and epigenetic markers, advanced MRI markers). An integrative model to predict disease progression will be proposed based on multimodal markers.

Enrollment

120 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Clinically isolated syndrome or Multiple sclerosis (2010 Mc Donald criteria)
Sibling having Clinically isolated syndrome or Multiple sclerosis (2010 Mc Donald criteria) willing to participate to the study
Affiliated to the French social security or equivalent

Exclusion criteria

Cyclophosphamide, mitoxantrone or methylprednisolone infusion within one month before inclusion
Multiple sclerosis relapse within one month before inclusion
Concomitant severe or uncontrolled disease