Mechanisms of Endothelial Dysfunction in Type 2 Diabetes (DIAB-EETs)

University Hospital, Rouen

Status: Completed

Conditions: Diabetes Mellitus, Type 2

Treatments: Biological: Blood samples

Study type: Interventional

Funder types: Other

Identifiers

NCT02311075

2013-A01107-38 (Other Identifier)

2013/049/HP

Details and patient eligibility

About

Endothelial dysfunction of conduit arteries plays an important role in the development of cardiovascular complications associated with type 2 diabetes. In order to propose targeted therapeutic approaches, this study aim to determine the mechanisms involved in endothelial dysfunction of conduit arteries in these patients.

Enrollment: 48 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Type 2 diabetic patients or control subjects or healthy volunteers

Exclusion criteria

• Macroangiopathy
• Insulin treatment
• Chronic kidney disease (eGFR<60 ml/min/m²)
• Hyperlipidemia (total cholesterol>2.5 g/l)
• Smoking habit > 5 cigarettes/day
• Pregnancy

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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48 participants in 3 patient groups

Patient comparative approach

Experimental group

Description:

Assessing the availability of biological markers (NO, EETs, ET-1 and ROS) during endothelial stimulation using blood samples.

Treatment:

Biological: Blood samples

Control subjects comparative approach

Experimental group

Description:

Assessing the availability of biological markers (NO, EETs, ET-1 and ROS) during endothelial stimulation using blood samples.

Treatment:

Biological: Blood samples

Healthy volunteers metabolic approach

Experimental group

Description:

Assessing the availability of biological markers (NO, EETs, ET-1 and ROS) during endothelial stimulation using blood samples during hyperglycemia or hyperinsulinemia.

Treatment:

Biological: Blood samples