Mechanisms of Fronto-Subcortical Dysfunction: Comparing PD and OCD

Sheba Medical Center

Status: Unknown

Conditions: Obsessive-Compulsive Disorder; Parkinson's Disease

Study type: Observational

Funder types: Other

Identifiers

NCT00790634

SHEBA-08-5473-SH-CTIL

Details and patient eligibility

About

The purpose of this study is to characterize and compare irregularities in dopaminergic function in fronto-subcortical circuits, between Parkinson's Disease patients (ON and OFF medication) and patients with obsessive-compulsive disorder, by examining performance on cognitive tasks involving cognitive flexibility, decision-making, and attentional bias.

Enrollment: 100 estimated patients

Sex: All

Ages: 16 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• idiopathic PD or
• OCD
• for control group - age-matched to study groups

Exclusion criteria

• psychotic symptoms (past or present)
• head injury with loss of consciousness
• other neurological conditions (excepting PD in PD group)
• for OCD group - use of dopaminergic medications

Trial design

100 participants in 4 patient groups

Parkinson's Disease

Description:

Patients with idiopathic Parkinson's disease

Obsessive-compulsive disorder

Description:

Individuals with a diagnosis of obsessive-compulsive disorder

OCD controls

Description:

Healthy controls, matched in age and number to obsessive-compulsive group

PD controls

Description:

Healthy controls, matched in age and number to Parkinson's disease group