Mechanisms of Lung Defense and Their Relationship With Airway Infection in Chronic Obstructive Pulmonary Disease (COPD)

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Status: Unknown

Conditions: Bacterial Infection in COPD

Treatments: Procedure: Bronchoscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT01976130

IIBSP-MUC-2009-20

Details and patient eligibility

About

Study hypothesis:

Chronic Obstructive Pulmonary Disease (COPD) patients with chronic bacterial colonization have lower levels of mucins and antimicrobial peptides in their airways

Full description

Main objective:

(1) To investigate the expression of mucins and antimicrobial peptides in patients with severe COPD and their relationship with the presence of bacteria in the airway

Enrollment: 45 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COPD

Exclusion criteria

• Acute exacerbation in the last 4 weeks

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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45 participants in 1 patient group

bronchoscopy

Experimental group

Description:

Procedure

Treatment:

Procedure: Bronchoscopy