Mechanisms of Manual Therapies in CAI Patients

University of North Carolina (UNC)

Status: Completed

Conditions: Chronic Instability of Joint; Ankle Inversion Sprain

Treatments: Other: Joint Mobilization; Other: Massage

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT03418051

17-2655

1R21AT009704-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

ABSTRACT:

Injury associated with sport and recreation is a leading reason for physical activity cessation, which is linked with significant long-term negative consequences. Lateral ankle sprains are the most common injuries associated with physical activity and at least 40% of individuals who sprain their ankle will go on to develop chronic ankle instability (CAI), a multifaceted condition linked with life-long residual symptoms and post-traumatic ankle osteoarthritis. Our long term goal is to develop intervention strategies to decrease disability associated with acute and chronic ankle injury and prevent posttraumatic ankle osteoarthritis. Conventional rehabilitation strategies, are only moderately successful because they ignore the full spectrum of residual symptoms associated with CAI. Manual therapies such as ankle joint mobilizations and plantar massage target sensory pathways not addressed by conventional treatments and have been shown to improve patient-reported outcomes, dorsiflexion range of motion, and postural control in CAI patients. While these early results are promising, the underlying neuromuscular mechanisms of these manual therapies remain unknown. Therefore the objective of this R21 proposal is to determine the neuromuscular mechanisms underlying the improvements observed following independent ankle joint mobilization and plantar massage interventions in CAI patients. To comprehensively evaluate the neuromuscular mechanisms of the experimental treatments, baseline assessments of peripheral (ankle joint proprioception, light-touch detection thresholds, spinal (H-Reflex of the soleus and fibularis longus), and supraspinal mechanisms (cortical activation, cortical excitability, and cortical mapping, sensory organization) will be assessed. Participants will then be randomly assigned to receive ankle joint mobilizations (n=20), plantar massage (n=20), or a control intervention (n=20) which will consist of 6, 5-minute treatments over 2-weeks. Post-intervention assessments will be completed within 48-hours of the final treatment session. Separate ANOVAs will assess the effects of treatment group (ankle joint mobilization, plantar massage, control) and time (baseline, post-treatment) on peripheral, spinal, and supraspinal neuromuscular mechanisms in CAI participants. Associations among neuromuscular mechanisms and secondary measures (biomechanics and postural control) will also be assessed. The results of this investigation will elucidate multifaceted mechanisms of novel and effective manual therapies (ankle joint mobilizations and plantar massage) in those with CAI.

Enrollment: 60 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria:

Individuals with Chronic Ankle Instability which will be defined as those individuals who:

• have sustained at least two lateral ankle sprains;
• have experienced at least one episode of giving way within the past 6-months;
• answer 4 or more questions of "yes" on the Ankle Instability Instrument;
• have self-assessed disability scores of ≤90% on the Foot and Ankle Ability Measure;
• have self-assessed disability scores ≤80% on the Foot and Ankle Ability Measure-Sport.

Exclusion criteria for Chronic Ankle Instability will include:

• known vestibular and vision problems,
• acute lower extremities and head injuries (<6 weeks),
• chronic musculoskeletal conditions known to affect balance (e.g., Anterior Cruciate Ligament deficiency) and
• a history of ankle surgeries to fix internal derangement.

Participants will also be excluded if they have any of the following which are contraindications to Transcranial Magnetic Stimulation testing:

• metal anywhere in the head (except in the mouth),
• pacemakers,
• implantable medical pumps,
• ventriculo-peritoneal shunts,
• intracardiac lines,
• history of seizures,
• history of stroke
• history of serious head trauma.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 3 patient groups

Control

No Intervention group

Description:

Control group that will receive no intervention throughout the duration of the study (2-weeks).

Joint Mobilization

Experimental group

Description:

Participants will receive 6, 5-minute treatment sessions over 2-weeks. Each session will consist of 2, 2-minute bouts of Grade III anterior-to-posterior talocrural joint mobilization with 1-minute between sets. Mobilizations will be large-amplitude, 1-s rhythmic oscillations from the mid- to end range of arthrokinematic motion.

Treatment:

Other: Joint Mobilization

Massage

Experimental group

Description:

Participants will receive 6, 5-minute treatment sessions over 2-weeks. Each session will consist of 2, 2-minute bouts of plantar massage bouts with 1-minute between sets. The massage will be a combination of petrissage and effleurage to the entire plantar surface.

Treatment:

Other: Massage