Mechanisms of Myocardial Infarction in Women With Non Obstructive Coronary Artery Disease

Rambam Health Care Campus

Status

Unknown

Conditions

Myocardial Infarction

Treatments

Procedure: cardiac imajing

Study type

Observational

Funder types

Other

Identifiers

NCT01953029

0541-12-RMB

Details and patient eligibility

About

The objective of our work to determine the mechanisms of myocardial infarction in women without obstructive coronary artery disease.

Full description

Cardiovascular disease is the leading cause of death for women. Acute coronary syndrome (ACS) is usually characterized by a sudden erosion of the endothelial wall or rupture of a plaque.However, women with ACS are less likely than men to have either classic symptoms or obstructive coronary artery disease but paradoxically have a worse prognosis. Different data from the literature indicate that there may be different pathophysiological mechanisms, afflicting men and women somewhat differently.Between 5% and 30% of patients with ACS undergoing coronary angiography are found to have non visible or non obstructive coronary disease (NOCD). This is 2-3 times more common in women than in men. Several pathogenetic mechanism of myocardial infarction (MI) in the absence of obstructive coronary artery disease (OCD) have been postulated, including among others atherosclerosis with plaque disruption that does not lead to luminal occlusion ,endothelial dysfunction, vasospasm , distal microembolization and microvascular dysfunction. However the data are extremely limited.

Enrollment

80 estimated patients

Sex

Female

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Women ≥ 18 years old, not pregnant
with acute non ST elevation myocardial infarction (admitted within 12 hours from beginning of symptoms)
who are candidates for coronary arteriography during the hospitalization. -

Exclusion criteria

*Women with troponin elevation caused by other causes -