Mechanisms of Orthopnea in Stable Obese Patients (OBAIRWAY)

Civil Hospices of Lyon

Status: Completed

Conditions: Obesity

Treatments: Other: Supine

Study type: Interventional

Funder types: Other

Identifiers

NCT02832609

2009-574

Details and patient eligibility

About

The purpose of this study is to study the role of closing volume as a determinant of orthopnea in stable obese subjects. The investigators hypothesized that: (1) increase in closing volume in supine position would be greater in orthopneic than in non-orthopneic subjects, and (2) the relationship of change in closing volume to change in dyspnea with position would be dependent on expiratory flow limitation in the sitting position.

In stable obese subjects, in sitting and supine positions, the investigators measured Borg dyspnea score, static lung volumes, expiratory flow limitation, and single-breath nitrogen expiration test, from which the investigators determined closing volume and closing capacity, slope of phase III, and opening capacity.

Orthopnea was defined as any increase in the Borg score in the supine position from its value in the sitting position

Enrollment: 30 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• obese (BMI ≥ 30)
• stable condition
• 20 < Age < 60 years

Exclusion criteria

• other respiratory disorder (COPD)
• left cardiac insufficiency

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

sitting position

No Intervention group

Description:

measurement in the sitting position

supine position

Active Comparator group

Description:

measurement in the sitting position

Treatment:

Other: Supine