Mechanisms of Stroke in Intracranial Stenosis (MoSIS)

Jose Romano, MD

Status: Terminated

Conditions: Stroke

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT01152944

1R01NS069938-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The objective of this SAMMPRIS-affiliated study is to understand the mechanisms the mechanisms that underlie ischemic stroke recurrence in high-grade intracranial atherosclerotic disease in order to determine predictors of recurrent stroke. MoSIS will evaluate 6 specific mechanisms of stroke in the medically-treated SAMMPRIS cohort: decreased antegrade flow, progression of stenosis, decreased proximal collateral flow, decreased distal collateral flow, impaired cerebrovascular reserve, and artery-to-artery embolism.

Enrollment: 100 patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Enrolled in the medical arm of SAMMPRIS, signed consent

Exclusion criteria

• For QMRA testing: contraindications to MRI; for TCD testing, abscence of ultrasonographic windows.