Mechanisms of Tissue Repair After Muscle Injury and Tendon Strain

Bispebjerg Hospital

Status: Completed

Conditions: Tendon Strain; Muscle; Injury, Quadriceps (Thigh)

Treatments: Other: Neuromuscular electrical stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT05809947

BBH150

Details and patient eligibility

About

The study is a 5-week human study including 24 18-35 year old healthy men. Each participant will have muscle injury and tendon strain induced in one leg using neuromuscular electrical stimulation in conjunction with forced lengthening contractions. The investigators will monitor the recovery from injury/strain over a 4 week period, in which half of the subjects will receive growth hormone (somatropin) to stimulate the connective tissue synthesis.

Enrollment: 25 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy men
• BMI between 18.5-30 kg/m^2

Exclusion criteria

• Smoking
• Regular strength training within the last 3 months
• Current or former use of anabolic steroids or growth hormone
• Use of corticosteroids in the last 3 months
• Use of blood thinning medication
• Use of medication which can affect muscle protein synthesis
• Current or former drug og alcohol abuse
• Knee pain
• Previous participation in studies using deuterated water or alanine tracers

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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25 participants in 2 patient groups, including a placebo group

Growth hormone/somatropin

Experimental group

Description:

Somatropin over two weeks (33.3 ug/kg/day in the first week, 50 ug/kg/day in the second week)

Treatment:

Other: Neuromuscular electrical stimulation

Placebo

Placebo Comparator group

Description:

Injections of placebo/saline over two weeks

Treatment:

Other: Neuromuscular electrical stimulation