Mechanisms of Type 1 Diabetes Endophenotypes (METYDIA)

Pediatric Clinical Research Platform

Status

Enrolling

Conditions

Type 1 Diabetes Mellitus

Genetic Predisposition to Disease

Treatments

Genetic: Genome sequencing

Study type

Observational

Funder types

Other

Identifiers

NCT05764850

2022-02119

Details and patient eligibility

About

The goal of this observational study consists of performing cluster analysis to decipher underlying disease mechanisms of type 1 diabetes in children and young adults.

To this end, we will combine clinical, laboratory, genetic, transcriptomic, and metabolomic datasets of an extensively phenotyped cohort of children and young adults with type 1 diabetes. We will also assess the risk for cardiovascular diseases in this most vulnerable diabetes cohort.

Enrollment

150 estimated patients

Sex

All

Ages

Under 25 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria (Type 1 Diabetic patients):

Informed consent as documented by signature
Patient's age: between 0 and 25 years old.
Children, adolescents, and young adult patients followed in diabetology.

Exclusion Criteria (Type 1 Diabetic patients):

No exclusion criteria

Inclusion Criteria (Controls):

Informed consent as documented by signature
Patient's age: 25 less than 6 years of age and 25 between 6 and 25 years old.
Healthy patient

Exclusion Criteria (Controls):

Patient receiving treatment affecting metabolic control (ex: systemic corticoids, beta blocker, immunotherapy etc.)
Concomitant disease that may affect the analysis of the results (ex: cancer, active autoimmune disease requiring treatment)