Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest

Helsinki University Central Hospital (HUCH)

Status: Completed

Conditions: Heart Arrest; Cardiac Arrest

Study type: Observational

Funder types: Other

Identifiers

NCT01968148

357/13/03/12/2012 § 205

Details and patient eligibility

About

The aim of the study is to describe the mechanisms of ultra-acute hyperglycemic response after return of spontaneous circulation (ROSC) in patients suffering out-of-hospital cardiac arrest. The investigators hypothesize that ischemia and reperfusion injury leads decreased secretion of insulin and glucose-like peptide 1 (GLP-1).

Two blood samples will be drawn: (1.) Immediately after ROSC and (2.) 60 minutes after first sample. Concentrations of glucose, insulin, glucagon and GLP-1 will be compared between the samples.

Metabolic profile will be compared between: (1.) diabetic and non-diabetic patients and (2.) survivors and non-survivors.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age ≥18 years
• witnessed cardiac arrest
• interval form emergency call to return of spontaneous circulation 10-45 minutes

Exclusion criteria

• severe pre-arrest disability leading to withdrawing treatment in prehospital phase
• no concent from next of kin