Mechanisms Underlying Cardiovascular Consequences Associated With COVID-19 and Long COVID

Columbia University

Status: Withdrawn

Conditions: COVID-19

Study type: Observational

Funder types: Other

Identifiers

NCT06427512

AAA-TBA

Details and patient eligibility

About

AIM 1. Characterize cardiovascular phenotypes of long COVID by cardiopulmonary, meta-bolic, and cardiac mechanical/physiological responses to exercise and microvascular vasomotor function.

AIM 2. Identify intercellular signaling between immune cells and cardiac cells associated with microvascular phenotypes of long COVID.

Full description

As many as 40-60% of patients who recovered from mild or moderate acute COVID have reported what is now called long COVID - multiple, persistent or recurrent symptoms lasting 6-9 months (or longer) following initial illness.1-4 Fatigue, dyspnea, and chest pain are the most common symptoms. Others include palpitations, lightheadedness, and syncope. All these cardiovascular symptoms can be debilitating, resulting in worse quality of life and morbidity.5, 6 Treatment options are limited.

Sex: All

Ages: 19 to 74 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18, < 75 yrs
• History of lab-confirmed COVID
• Symptomatic at >12 wks post-acute COVID (cases)
• Recovered by 8wks post-acute COVID (controls)

Exclusion criteria

• Any history of critical illness
• Chronic kidney disease, Stage >4
• Pre-COVID: HFrEF, CABG, arrhythmia; pulmonary hypertension, pulmonary embolus, interstitial lung disease (ILD), O2 dependence; dementia, stroke, autonomic dysfunction; coagulopathy
• Post-COVID: ILD, O2 dependence

Trial design

0 participants in 1 patient group

COVID patients

Description:

Patients with long COVID-19 and experiencing cardiovascular symptoms at 24 weeks post-acute illness or post-COVID without cardiovascular symptoms by 8 weeks after illness.