Mechanisms Underlying Impaired Diabetic Wound Healing (WoundVac)

University of Pittsburgh

Status: Enrolling

Conditions: Non-healing Wounds; Diabetes

Treatments: Other: Blood draw

Study type: Observational

Funder types: Other

Identifiers

NCT00777712

STUDY23070132

Details and patient eligibility

About

The overall aim of this research is to utilize wound derived inflammatory cells from diabetic versus non diabetic human chronic wounds to understand mechanisms that are responsible for disregulated inflammation in individuals with diabetes. Biology of normal (peripheral blood derived cells) versus wound derived cells will also be studied.

Full description

Specific aims:

1. To study biology of wound derived inflammatory cells and fluid from diabetic versus non diabetic wounds.
2. To characterize mechanisms that are responsible for dysregulated wound inflammatory cell function in individuals with diabetes.
3. To characterize differences in the biology of normal peripheral blood derived cells versus wound derived cells.

The long-term goal of this study is to determine the molecular mechanisms underlying impaired wound healing in diabetics.

Enrollment: 250 estimated patients

Sex: All

Ages: 21 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ages 21-80
• Chronic Wound (present >4 weeks)
• Diabetic & Non-diabetic
• Adult surgical wounds

Exclusion criteria

• Inability to consent
• Pregnant women
• Therapeutically immunocompromised
• Individuals defined in 45 CFR 46 Subparts B,C, and D, nor from any other population considered vulnerable 2.9

Trial design

250 participants in 1 patient group

Diabetic wound study

Description:

Patients with diabetes or no diabetes

Treatment:

Other: Blood draw