Mechanistic and Molecular Study of the Process of Metastatic Dissemination in Colorectal Cancer (DISCOVER)

Gustave Roussy

Status: Unknown

Conditions: Colorectal Cancer

Treatments: Procedure: Sampling

Study type: Interventional

Funder types: Other

Identifiers

NCT03613194

2017/2511 (Other Identifier)

2017-A02878-45

Details and patient eligibility

About

To confirm the role of the collective dissemination in the mechanisms of tumoral invasion of colorectal cancers

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years
• Histological Diagnosis of stage IV colorectal cancer
• Hepatic metastasis and/or peritoneal potentially resecable
• Patient affiliated with a mode of the social security or recipient of such a mode
• Information of the patient or his legal representative and collection of his assent

Exclusion criteria

• None metastatic colorectal cancer
• Cancer of appendicular origin
• Patients deprived of liberty or unable to give his assent

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

Patients with metastatic colorectal cancer

Other group

Description:

After inclusion in the study, eligible patients having hepatic metastases and/or péritonéales of a colorectal cancer considered as resecables will have biological and tissue samples. The samples will be carried out at the time of the surgical gesture envisaged under general anaesthesia and will concern: * Tumoral material: primitive tumour (if available), hepatic metastases and/or peritoneal * Peritoneal liquid * none tumoral peritoneum * Portal blood * Peripheral blood * Cellulo-lymphatic material The necessary time to carry out the whole of these samples is estimated at 10-15 minutes maximum. In the event of complex situations being able to complicate the surgical gesture initially envisaged or to increase by them morbidity, one or more these samples will not be carried out. This decision will be made at the discretion of the investigator.

Treatment:

Procedure: Sampling