Mechanistic Studies on Video-guided Acupuncture Imagery Treatment of Knee Pain

Mass General Brigham

Status: Completed

Conditions: Osteoarthritis, Knee

Treatments: Device: Acupuncture

Study type: Interventional

Funder types: Other

Identifiers

NCT03261505

2017P000820

Details and patient eligibility

About

The aim of this study is to investigate brain response and connectivity changes evoked by video-guided acupuncture imagery treatment (VGAIT) and verum and sham acupuncture in knee osteoarthritis patients to elucidate the underlying brain mechanisms of mind-body interaction, imagery, and acupuncture.

Enrollment: 125 patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Right-handed
• Knee osteoarthritis patients
• Ages 40 to 70 years old

Exclusion criteria

• Any contraindications to MRI scanning (claustrophobia, metal implants)
• Current or past history of major medical, neurological, or psychiatric illness other than knee osteoarthritis (including high blood pressure, heart disorders, impaired elimination, stomach problems, major kidney or liver problems, bleeding problems, severe dehydration, history of diabetes, history of asthma or other respiratory condition)
• Pregnancy
• Non fluent English speaker

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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125 participants in 4 patient groups, including a placebo group

VGAIT

Experimental group

Treatment:

Device: Acupuncture

VGAIT Control

Sham Comparator group

Treatment:

Device: Acupuncture

Real Acupuncture

Active Comparator group

Treatment:

Device: Acupuncture

Sham Acupuncture

Placebo Comparator group

Treatment:

Device: Acupuncture