Median Sevoflurane Concentration for Hypotension Between Young and Elderlypatients: Adaptive Clinical Trial

Brasilia University Hospital

Status and phase: Unknown; Phase 4

Conditions: Hypotension

Treatments: Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT03595319

TccFeliciaVictor2018

Details and patient eligibility

About

Two arms: elder group, young group. Dixon's up and down adaptive methodology for ED50. Executed after Anesthesia induction for 10min without touching the patient after starting mechanical ventilation.

Full description

This adaptive clinical trial will vary target end tidal sevoflurane by 0.4, then by 0.2 and by 0.1 thereafter in order to minimize sample size.

Enrollment: 40 estimated patients

Sex: All

Ages: 19 to 120 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Understands experiment, is voluntary, signs informed consent;
• Does not take medication that influences arterial pressure;
• Normotensive.

Exclusion criteria

• Received any medication that influences arterial pressure before experiment;

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Sequential Assignment

Masking: Single Blind

---

40 participants in 2 patient groups

Young patients

Experimental group

Description:

Patients between 19 and 40 years-old

Treatment:

Drug: Sevoflurane

Elder patients

Experimental group

Description:

Older than 65

Treatment:

Drug: Sevoflurane